SPV · TMS · Keta · Pacific Northwest, CA
You've Been Managing Symptoms, Now Experience Relief
If regular antidepressants haven't worked for you, you're not the problem. You may just need a different approach. Psycle Health connects you with an interventional psychiatry clinic near you that offers SPV, TMS, and IV Keta: Three FDA-backed pathways to targeting depression more directly. A free evaluation matches you with the treatment that's right for you.
Why these treatments
Targeting where antidepressants can’t reach.
SPV, TMS, and IV Keta work through entirely different pathways than traditional SSRIs. That's why they can help the many people whose depression has other origins.
They work in hours and days, not months
Antidepressants force a 1 to 4+ week waiting game. SPV and IV Keta can produce measurable symptom relief within 24 hours. TMS typically shows response within 1 - 3 weeks.
Reduced risk of sexual dysfunction
Up to 70% of SSRI and SNRI users experience sexual side effects. SPV reports under 1%. TMS and IV Keta carry effectively zero risk.
They work on multiple levels, not just your serotonin system
TMS directly stimulates the brain's mood center. SPV and Keta act on NMDA glutamate receptors to trigger synaptogenesis ~ your brain literally grows new connections.
SPV, IV Keta and TMS can work when everything else has failed
TMS shows roughly 70% response rates. SPV achieves around 65%. IV Keta reports response rates near 70% in published studies. Compare that to 46% from antidepressants alone.
No weight gain. No metabolic roulette
TMS has zero systemic effects. SPV transient side effects resolve within hours of each session, and IV Keta's effects clear similarly fast.
Defined finish lines to your course of treatment
Many patients stay on antidepressants indefinitely. TMS completes in about 6 weeks. A Keta series is typically 6 sessions over 2 - 3 weeks. SPV has a clear induction-then-maintenance schedule.
See it in action
What we offer
Three evidence-based routes to wellness.
An antidepressant nasal spray that can work fast.
SPV (esketa) acts on the glutamate system ~ a different brain pathway than is targeted by SSRIs. Effects on depression can be measurable within 24 hours. Sessions happen in-clinic with two hours of monitoring. • FDA-approved 2019 • In-clinic, 2-hour visit • Twice weekly × 4 weeks, then maintenance
A drug-free, non-invasive treatment
TMS uses gentle magnetic pulses to reactivate parts of your brain depression has subdued. No medications, no sedation. Sessions are about 20 minutes and you drive yourself home. • FDA-cleared 2008 • ~20 min, drive yourself home • 5 days a week × 6 weeks, then taper
IV Keta therapy with in-clinic care.
IV Keta acts on the same glutamate pathway as SPV, delivered as a 40-minute infusion in-clinic. Often a fit when other paths aren't, or when faster relief is needed. Used off-label for treatment-resistant depression. • Used off-label since the 2000s • ~40 min IV infusion in-clinic • Typically 6 sessions over 2 - 3 weeks, IV Keta therapy with in-clinic care.
You don't need to choose today. When we connect you with your psychiatrist, they will recommend the right option during your free evaluation, based on your history and your goals.
Your brain is healingYour brain is healingInsurance & cost
We'll handle the paperwork & process, together.
SPV and TMS are covered by most major commercial insurance plans and Medicare for adults whose depression hasn't responded to medication, with prior authorization. IV Keta is used off-label, so coverage is less consistent ~ but some plans reimburse, and the partner clinic offers transparent self-pay pricing where it doesn't. We check your benefits across all three options, prepare the approval request for whichever path you and your psychiatrist choose, and tell you exactly what your out-of-pocket cost will look like before you start. At no charge.
Most plans
SPV and TMS covered with prior authorization
1 - 2 weeks
Typical insurance approval turnaround
Free
Evaluation and benefits check at no cost
In their words.
"This treatment has changed my life. I have really seen the difference and so has my family. After years of struggling, I'm finally off all of my psychiatric medications that were causing more harm than any good they were providing. I'm so grateful I took a risk and clicked the facebook ad I saw!"
Destiny, Age 38
"I didn't know it was possible for me to receive something for my TRD. I always thought something was wrong with me or I was taking the medication wrong. I’m in tears knowing there’s something out there for me to try to be happy again."
Mike, Age 32
"I literally could cry right now, I'm so excited to just try and see if SPV Therapy works. I'm just so sick of nothing working; it sucks, and it's hard to get people to understand what you're going through because they just don't. Thank you so so so much, I appreciate you, you might've just changed my life."
Christina, Age 35
"I've been suffering for so many years. I'm sorry, I don't mean to get emotional I just can't remember what it feels like to be motivated or inspired and this treatment sounds hopeful. I'm so grateful I answered the phone."
Gavin, Age 29
"I've been dealing with this for so long and nothing has ever worked. Hearing that there's something that can actually help, and fast, I don't know, it just makes me feel like maybe things can actually get better. This is the first time I've felt hopeful in a long time."
Ella, Age 31
"I sat in that chair for an hour and came out with thirty years of junk cleared out of my head. That, to me, was a miracle. I haven't felt this good in probably three decades. It works. You can go from feeling like trash to feeling normal in the span of two hours. If you're on the fence, don't be. They'll treat you well, and you'll feel amazing when you leave."
Doug M.
Ready to get support?
- No commitment
- Real humans
- Free verification
- HIPAA-compliant
How to get started
We've made this as simple as we can.
01
Check
Take the 30-second quiz and share your insurance details so we can check coverage for free.
02
Consult
Meet with a Psycle Health Care Coordinator to confirm if a partner clinic is a fit.
03
Evaluate
Speak with a licensed medical professional to confirm you're a candidate.
04
Authorize
The clinic will submit a prior authorization to your insurance, which takes 5-7 days on average.
05
Improve
Begin twice-weekly starting sessions, with our team supporting you through every visit.
Frequently asked questions about the evaluation.
A licensed psychiatrist at the partner clinic near you reviews your antidepressant history, your current symptoms, and any safety factors. Together you'll discuss whether SPV, TMS, IV Keta, or another path is the best fit. The evaluation is the right place to decide, together with the clinician who is there to support you in accessing care. Psycle Health verifies your insurance for free in parallel.
No. The evaluation is there to help you with making this choice. Your psychiatrist recommends a path based on your history, your goals, and your safety profile. Many patients qualify for more than one option; some only fit one. That's what the clinical conversation is for.
About 45 - 60 minutes for the clinical visit, plus a brief intake call beforehand to verify insurance and gather records. Most patients leave the evaluation with a clear next step and a starting date if they want to proceed with either SPV, IV Keta or TMS.
Yes. The partner clinic we'll refer you to doesn't charge for the initial consultation. Insurance verification through Psycle Health is also free. And there's no obligation to start treatment.
SPV is an FDA-approved nasal spray for adults whose depression hasn't responded to at least two oral antidepressants. It works on the glutamate system, can produce measurable effects within 24 hours, and is taken in-clinic with two hours of monitoring afterward.
TMS (transcranial magnetic stimulation) is an FDA-cleared treatment that uses gentle magnetic pulses to reactivate the part of the brain that depression has quieted. Sessions are about 20 minutes, drug-free, with no sedation. A standard course runs five days a week for six weeks.
Keta is the original molecule that SPV is derived from, delivered as an intravenous infusion in-clinic. It's used off-label for treatment-resistant depression and acts on the same glutamate pathway as SPV. A typical induction series is six 40-minute infusions over 2 - 3 weeks. Because it's off-label, insurance coverage varies and many clinics offer self-pay options.
Most major commercial plans and Medicare cover SPV and TMS for adults whose depression hasn't responded to medication, with prior authorization. IV Keta is off-label, so insurance coverage is less common, but some plans reimburse, and the clinic will tell you what to expect. Psycle Health checks all three, and your personal options for accessing care, for free.
We'll tell you honestly and walk you through your alternative pathways. The evaluation is not a sales pitch, it's a realistic review of your medical history and circumstances, and which treatments can work for you right now. If a different path is right for you or one of these options could be suitable in the future, we'll help you towards it.
Fill out the form. A Psycle Health care coordinator calls within 24 hours to verify your insurance and book the evaluation with the clinic nearest you. From form to evaluation is usually under a week.
You haven't run out of options. You may just not have been offered the right ones yet.
Schedule a free evaluation. We'll verify your insurance, talk through your history, and together with a psychiatrist, we'll map a real next step.